Ezetimibe is most useful in people who cannot take statins or as yet another drug for those who take statins but notice unwanted effects when the statin dose is improved. Adding ezetimibe to a statin escalates the cholesterol-lowering impact by a 2 – to 3-fold element. Who should not use these medications? Individuals who are allergic to ezetimibe should not take it. Use: Ezetimibe is used once daily, with or without meals. It is often combined with statins to improve effectiveness.Maintaining a normal level of this protein might be effective in preventing weight problems – and age-related diseases. Related StoriesPoverty and parenting design predict childhood obesityNew Cleveland Clinic research shows bariatric surgery is safe option for managing type 2 diabetes in obese or mildly obese patientsObesity organizations take aim at claims that deny insurance coverage of weight problems treatment under affordable care act Metabolic stress due to obesity, diabetes and aging boosts a small molecule, glutathione that reacts with SirT1, inhibiting its activity.